Gene: FGFR2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2981582
rs2981582
FGFR2
0.800 GeneticVariation BEFREE P21 Ser31Arg and FGFR2 rs2981582 Polymorphisms as Risk Factors for Early Onset of Breast Cancer in Yogyakarta, Indonesia. 31759353

2019
dbSNP: rs779848635
rs779848635
FGFR2
0.010 GeneticVariation BEFREE P21 Ser31Arg and FGFR2 rs2981582 Polymorphisms as Risk Factors for Early Onset of Breast Cancer in Yogyakarta, Indonesia. 31759353

2019
dbSNP: rs2981578
rs2981578
FGFR2
0.790 GeneticVariation BEFREE The results suggest these polymorphisms, especially rs1966265 and rs2981578, might be candidate pharmacogenomics factors to the response and prognosis prediction for individualized CET-based chemotherapy in breast cancer patients. 30359238

2018
dbSNP: rs2981582
rs2981582
FGFR2
0.800 GeneticVariation BEFREE The association of the fibroblast growth factor receptor 2 gene (<i>FGFR2</i>) polymorphism rs2981582 with breast cancer has been extensively studied, whereas the role of this polymorphism in non-functioning pituitary adenoma (NFPA) has not been elucidated. 30206133

2018
dbSNP: rs1219648
rs1219648
FGFR2
0.800 GeneticVariation BEFREE The SNPs of FGFR2 rs1219648 and PI3KCA rs6443624 may contribute to the identification of breast cancer patients at risk of more aggressive disease and may be potential prognostic factors in breast cancer in a Chinese population. 29872343

2018
dbSNP: rs1219648
rs1219648
FGFR2
0.800 GeneticVariation BEFREE This meta-analysis of case-control studies provides strong evidence that fibroblast growth factor 2 (FGFR2; rs11200014, rs2981579, and rs1219648) polymorphisms are significantly associated with the BC risk. 29390357

2017
dbSNP: rs2981579
rs2981579
FGFR2
0.740 GeneticVariation BEFREE This meta-analysis of case-control studies provides strong evidence that fibroblast growth factor 2 (FGFR2; rs11200014, rs2981579, and rs1219648) polymorphisms are significantly associated with the BC risk. 29390357

2017
dbSNP: rs2981582
rs2981582
FGFR2
0.800 GeneticVariation BEFREE This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphisms and breast cancer, to analyse the discriminative ability of each SNP and to test the accuracy of the predictive breast cancer risk model which includes all SNPs. 29372690

2017
dbSNP: rs2981578
rs2981578
FGFR2
C 0.790 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2017
dbSNP: rs35054928
rs35054928
FGFR2
GC 0.710 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2017
dbSNP: rs10510097
rs10510097
FGFR2
T 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2017
dbSNP: rs45631563
rs45631563
FGFR2
A 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683

2017
dbSNP: rs2981582
rs2981582
FGFR2
0.800 GeneticVariation BEFREE BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> . 28757652

2017
dbSNP: rs2981582
rs2981582
FGFR2
0.800 GeneticVariation BEFREE This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk. 27966449

2017
dbSNP: rs2981578
rs2981578
FGFR2
0.790 GeneticVariation BEFREE This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk. 27966449

2017
dbSNP: rs2420946
rs2420946
FGFR2
0.770 GeneticVariation BEFREE This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk. 27966449

2017
dbSNP: rs3135718
rs3135718
FGFR2
0.700 GeneticVariation GWASCAT Strong association between the FGFR2 locus and ER status of breast cancer patients was observed (ER-positive n=6211, ER-negative n=2516; rs3135718 OR=1.34 p=5.46×10-12). 27764800

2016
dbSNP: rs3135724
rs3135724
FGFR2
0.700 GeneticVariation GWASCAT GWAS in the SIGNAL/PHARE clinical cohort restricts the association between the FGFR2 locus and estrogen receptor status to HER2-negative breast cancer patients. 27764800

2016
dbSNP: rs2981578
rs2981578
FGFR2
0.790 GeneticVariation BEFREE We first validated that the SNPs rs12922061, rs2290203, and rs2981578 were associated with overall breast cancer risk in southeast Chinese women, with the per-allele OR of 1.209 (95%CI: 1.064-1.372), 1.176 (95%CI: 1.048-1.320), and 0.852 (95%CI: 0.759-0.956), respectively. 27705907

2016
dbSNP: rs1219648
rs1219648
FGFR2
0.800 GeneticVariation BEFREE Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women. 27572905

2016
dbSNP: rs2981582
rs2981582
FGFR2
0.800 GeneticVariation BEFREE Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women. 27572905

2016
dbSNP: rs35054928
rs35054928
FGFR2
0.710 GeneticVariation BEFREE We confirmed ten risk-associated variants within three reported breast cancer susceptibility loci in a Chinese Han population: 5q11.2 (rs16886181, P = 5.29 × 10(-6), OR = 1.19; rs1017226, P = 5.24 × 10(-4), OR = 1.22; rs16886034, P = 2.00 × 10(-3), OR = 1.21; rs16886113, P = 1.24 × 10(-3), OR = 1.20; rs16886364, P = 9.20 × 10(-4), OR = 1.21; rs16886397, P = 1.17 × 10(-3), OR = 1.20; rs16886448, P = 1.62 × 10(-3,)OR = 1.20; and rs2229882, P = 5.14 × 10(-4), OR = 1.31), 5q14.3 (rs421379, P = 2.83 × 10(-13), OR = 1.83), and 10q26.1 (rs35054928, P = 7.73 × 10(-6), OR = 1.18). 27572337

2016
dbSNP: rs1219648
rs1219648
FGFR2
G 0.800 GeneticVariation GWASCAT Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. 27354352

2016
dbSNP: rs2981582
rs2981582
FGFR2
A 0.800 GeneticVariation GWASCAT Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. 27354352

2016
dbSNP: rs2981579
rs2981579
FGFR2
A 0.740 GeneticVariation GWASCAT Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. 27354352

2016